Longitudinal Study of HTLV‐III‐Infected Chimpanzees by Lymphocyte Subpopulation Analysis
- 1 December 1985
- journal article
- research article
- Published by Wiley in Journal of Medical Primatology
- Vol. 14 (6) , 317-326
- https://doi.org/10.1111/j.1600-0684.1985.tb00272.x
Abstract
Following inoculation with plasma from human patients with AIDS, two chimpanzees demonstrated specific antihuman T‐cell leukemia virus type 3 (HTLV‐III) antibodies. One of the two chimpanzees also developed massive lymphadenopathy that persisted for 32 weeks and demonstrated a concurrent and more frequent depression of total T cells (T3) and T helper cells (T4) with a decrease in the ratios of T4 to T suppressor cells (T8). These results indicate that chimpanzees demonstrate a range of T‐cell subpopulations during infection and disease induced by HTLV‐III.Keywords
Funding Information
- U.S. Public Health Service
- National Heart, Lung, and Blood Institute (NO1‐HB‐2‐7004, NO1‐CL‐1‐2115, HL‐32505)
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