Human Cytomegalovirus Mutant with Sequence-Dependent Resistance to the Phosphorothioate Oligonucleotide Fomivirsen (ISIS 2922)
- 1 April 1998
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 42 (4) , 971-973
- https://doi.org/10.1128/aac.42.4.971
Abstract
A human cytomegalovirus mutant that was isolated for resistance (10-fold) to the antisense oligonucleotide fomivirsen (ISIS 2922) exhibited cross-resistance to a modified derivative of fomivirsen with an identical base sequence but little or no resistance to an oligonucleotide with an unrelated sequence. No changes in the mutant’s DNA corresponding to the fomivirsen target sequence were found.Keywords
This publication has 14 references indexed in Scilit:
- Inhibition of human cytomegalovirus immediate-early gene expression by an antisense oligonucleotide complementary to immediate-early RNAAntimicrobial Agents and Chemotherapy, 1996
- Antiviral activity of a phosphorothioate oligonucleotide complementary to RNA of the human cytomegalovirus major immediate-early regionAntimicrobial Agents and Chemotherapy, 1993
- Antisense Nucleic Acids — Prospects for Antiviral InterventionAntiviral Chemistry and Chemotherapy, 1993
- A point mutation in the human cytomegalovirus DNA polymerase gene confers resistance to ganciclovir and phosphonylmethoxyalkyl derivativesAntimicrobial Agents and Chemotherapy, 1993
- Isolation of Foscarnet-Resistant Human Cytomegalovirus Patterns of Resistance and Sensitivity to Other Antiviral DrugsThe Journal of Infectious Diseases, 1991
- The implications of resistance to antiviral agents for herpesvirus drug targets and drug therapyAntiviral Research, 1991
- Mutations in the herpes simplex virus major DNA-binding protein gene leading to altered sensitivity to DNA polymerase inhibitorsVirology, 1985
- Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locusJournal of Virology, 1985
- A WORKING HYPOTHESIS—VIRUS RESISTANCE DEVELOPMENT AS AN INDICATOR OF SPECIFIC ANTIVIRAL ACTIVITYAnnals of the New York Academy of Sciences, 1977