Genetic epidemiology of type 1 diabetes
- 16 June 2003
- journal article
- review article
- Published by Hindawi Limited in Pediatric Diabetes
- Vol. 4 (2) , 87-100
- https://doi.org/10.1034/j.1399-5448.2001.00013.x
Abstract
Family and twin studies indicate that a substantial fraction of susceptibility to type 1 diabetes is attributable to genetic factors. These and other epidemiologic studies also implicate environmental factors as important triggers. Although the specific environmental factors that contribute to immune-mediated diabetes remain unknown, several of the relevant genetic factors have been identified using two main approaches: genome-wide linkage analysis and candidate gene association studies. This article reviews the epidemiology of type 1 diabetes, the relative merits of linkage and association studies, and the results achieved so far using these two approaches. Prospects for the future of type 1 diabetes genetics research are considered.Keywords
This publication has 155 references indexed in Scilit:
- Type 1A Diabetes Induced by Infection and ImmunizationJournal of Autoimmunity, 2001
- Conditional ETDT analysis of the Human Leukocyte Antigen region in type 1 diabetesAnnals of Human Genetics, 2000
- Missense Variations of the Gene Responsible for Wolfram Syndrome (WFS1/wolframin) in Japanese: Possible Contribution of the Arg456His Mutation to Type 1 Diabetes as a Nonautoimmune Genetic BasisBiochemical and Biophysical Research Communications, 2000
- Incidence of Type 1 diabetes mellitus in children aged 0–14 in Japan, 1986–1990, including an analysis for seasonality of onset and month of birth: JDS studyDiabetic Medicine, 2000
- Sex difference in the incidence of insulin-dependent diabetes mellitus: an analysis of the recent epidemiological dataDiabetes/Metabolism Research and Reviews, 1997
- Insulin VNTR allele-specific effect in type 1 diabetes depends on identity of untransmitted paternal alleleNature Genetics, 1997
- Mutations in the hepatocyte nuclear factor-4α gene in maturity-onset diabetes of the young (MODY1)Nature, 1996
- Genetic dissection of complex traits: guidelines for interpreting and reporting linkage resultsNature Genetics, 1995
- Detection of an Alteration in the Insulin-Receptor Gene in a Patient with Insulin Resistance, Acanthosis Nigricans, and the Polycystic Ovary Syndrome (Type A Insulin Resistance)New England Journal of Medicine, 1988
- Differences in Risk of Insulin-Dependent Diabetes in Offspring of Diabetic Mothers and Diabetic FathersNew England Journal of Medicine, 1984