Oxidation of methyl groups by grass grubs and vertebrate liver enzymes

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Abstract
Oxidation rates of p-nitro-toluene p-acetamidotoluene and p-toluidine by intact grass grubs and vertebrate liver preparations were measured. The effect of p-substitu-tion in increasing the rate of conversion of the methyl into a carboxy group was in the order acetamido > nitro amino in mice and grass grubs. Rates of oxidation of the N-methyl group in some alkylaryl N-methylcarbamates were measured and the effect of ring substituents in increasing the rate was in the order hydrogen > o-methyl or o-iso-propyl > p-methyl or p-isopropyl > m-methyl or m-isopropyl. Rates of oxidation of the N-methyl groups were similar to those of the p-sub-stituted toluenes.