STUDIES ON THE ROLE OF HISTAMINE IN HUMAN PITUITARY FUNCTION

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Abstract
To elucidate further the role of histamine in pituitary regulation, TRH [thyroliberin] and L-dopa stimulation tests were performed with and without diphenhydramine, cimetidine or betazole pre-treatment. Betazole blunted the growth hormone response to L-dopa and slightly enhanced the triiodothyronine response to TRH without altering the thyrotropin or prolactin increments. Neither diphenhydramine nor cimetidine had any acute effect on the hormonal responses examined. Histamine appears to play only a limited role in these aspects of human pituitary regulation.