DIFFERENTIATION OF BENIGN MONOCLONAL GAMMOPATHY AND SMOULDERING MULTIPLE-MYELOMA FROM FRANK MYELOMA

  • 1 January 1982
    • journal article
    • research article
    • Vol. 50  (3) , 596-600
Abstract
Circulating Ig secreting cells of each type of the different Ig classes were enumerated using a reverse hemolytic plaque assay in 9 patients with the pre-clinical phase of IgG myeloma (6 with benign monoclonal gammopathy and 3 with smouldering multiple myeloma). A shift in the ratio of IgG.kappa. to IgG.lambda. secreting cells without a significant increase in the total number of IgG secreting cells (i.e., the number of IgG.kappa. plus IgG.lambda. secreting cells) was a constant feature noted in every subject.