Crystallization and preliminary X‐ray analysis of a PNA‐DNA complex
- 17 April 1995
- journal article
- Published by Wiley in FEBS Letters
- Vol. 363 (1-2) , 115-117
- https://doi.org/10.1016/0014-5793(95)00294-j
Abstract
Peptide nucleic acids (PNAs) are DNA mimics with a peptide backbone. PNAs are being intensely investigated owing to a potential as gene-targeted drugs. A PNA (H-GTAGAT-CACT-NH 2 )-DNA (5′-AGTGATCTAC-3′) complex has been crystallized in a tetragonal space group P4 1 22 with cell dimensions a = b = 79.8, c = 99.9 A ̊ . The crystals diffract to about 5 Å resolution.Keywords
This publication has 15 references indexed in Scilit:
- Solvent content of protein crystalsPublished by Elsevier ,2006
- Synthesis of Peptide Nucleic Acid Monomers Containing the Four Natural Nucleobases: Thymine, Cytosine, Adenine, and Guanine and Their OligomerizationThe Journal of Organic Chemistry, 1994
- Structural Characterization of PNA-DNA Duplexes by NMR. Evidence for DNA in a B-like ConformationBiochemistry, 1994
- Normalization factors for Kubic harmonic density functionsActa Crystallographica Section A Foundations of Crystallography, 1994
- DNA-like double helix formed by peptide nucleic acidNature, 1994
- Peptide nucleic acid (PNA). A DNA mimic with a peptide backboneBioconjugate Chemistry, 1994
- PNA hybridizes to complementary oligonucleotides obeying the Watson–Crick hydrogen-bonding rulesNature, 1993
- Antisense and Antigene Properties of Peptide Nucleic AcidsScience, 1992
- Sequence-Selective Recognition of DNA by Strand Displacement with a Thymine-Substituted PolyamideScience, 1991
- The protein data bank: A computer-based archival file for macromolecular structuresJournal of Molecular Biology, 1977