Limited proteolysis of MP26 in lens fiber plasma membranes of the U18666A-induced cataract in rats

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Abstract
Most of the animals treated with U18666A every other day beginning at one-day of age developed permanent nuclear cataracts by 3–4 weeks of age. Lens fiber plasma membranes were isolated from cortical and nuclear areas of untreated controls, treated but clear, and treated cataractous lenses, and analyzed by SDS-PAGE. MP26 was the major intrinsic polypeptide in the plasma membranes of both cortical and nuclear fibers of control lenses. MP26 was largely replaced by MP23–24 in the plasma membranes of nuclear fibers of treated but clear lenses, and in the membranes of both cortical and nuclear fibers of cataractous lenses.