DNA fingerprints revealing common and divergent human DNA methylation patterns
- 25 September 1989
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 255 (2) , 226-230
- https://doi.org/10.1016/0014-5793(89)81096-8
Abstract
We compared DNA fingerprints of different cell populations from the same individuals, after separate digestion with the isoschizomers MboI and Sau3A. Methylation differences were observed within every individual when comparing fingerprints of Sau3A- with MboI-digested DNA, and of Sau3A-digested sperm with somatic DNA. In some cases, differences were also detected between fingerprints of Sau3A-digested somatic DNA originating from various cell sources. Methylation patterns common to all cell populations examined, including the germline, were observed with a higher frequency than divergent ones. These ‘common methylations’ are most likely to find their origin during early embryogenesisKeywords
This publication has 12 references indexed in Scilit:
- Detection of specific sequences among DNA fragments separated by gel electrophoresisPublished by Elsevier ,2006
- The Duffy blood group is linked to the α-spectrin locus in a large pedigree with autosomal dominant inheritance of Charcot-Marie-Tooth disease type 1Human Genetics, 1988
- A Sequence in M13 Phage Detects Hypervariable Minisatellites in Human and Animal DNAScience, 1987
- Forensic application of DNA ‘fingerprints’Nature, 1985
- Individual-specific ‘fingerprints’ of human DNANature, 1985
- Hypervariable ‘minisatellite’ regions in human DNANature, 1985
- Genomic sequencing.Proceedings of the National Academy of Sciences, 1984
- De novo methylation and expression of retroviral genomes during mouse embryogenesisNature, 1982
- A methodological study of E-rosette formation using AET-treated sheep red blood cellsJournal of Immunological Methods, 1979
- The Glomerular Permeability Determined by Dextran Clearance Using Sephadex Gel FiltrationScandinavian Journal of Clinical and Laboratory Investigation, 1968