Hypervariable ‘minisatellite’ regions in human DNA
- 1 March 1985
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 314 (6006) , 67-73
- https://doi.org/10.1038/314067a0
Abstract
The human genome contains many dispersed tandem-repetitive minisatellite regions detected via a shared 10-15-base pair core sequence similar to the generalized recombinations signal (x) of Escherichia coli. Many minisatellites are highly polymorphic due to allelic variation in repeat copy number in the minisatellite. A probe based on a tandem-repeat of the core sequence can detect many highly variable loci simultaneously and can provide an individual-specific DNA fingerprint of general use in human genetic analysis.This publication has 36 references indexed in Scilit:
- Genetic mapping of the human X chromosome by using restriction fragment length polymorphisms.Proceedings of the National Academy of Sciences, 1984
- Somatic deletion and duplication of genes on chromosome 11 in Wilms' tumoursNature, 1984
- Development of homozygosity for chromosome 11p markers in Wilms' tumourNature, 1984
- Loss of alleles at loci on human chromosome 11 during genesis of Wilms' tumourNature, 1984
- DNA restriction fragment length polymorphisms and heterozygosity in the human genomeHuman Genetics, 1984
- A polymorphic DNA marker genetically linked to Huntington's diseaseNature, 1983
- Expression of recessive alleles by chromosomal mechanisms in retinoblastomaNature, 1983
- Linkage relationship of a cloned DNA sequence on the short arm of the X chromosome to Duchenne muscular dystrophyNature, 1982
- Estimation of genetic variation at the DNA level from restriction endonuclease data.Proceedings of the National Academy of Sciences, 1981
- DNA sequence variants in the Gγ-, Aγ-, δ- and β-globin genes of manCell, 1979