Significant Formation of 8-Hydroxydeoxyguanosine in Photoirradiation of “Photo-Fenton Reagent” with Calf Thymus DNA and L 5178Y cells
- 1 March 1993
- journal article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 22 (3) , 453-456
- https://doi.org/10.1246/cl.1993.453
Abstract
A significant formation of 8-hydroxydeoxyguanosine (8-OHdG) was observed in photoirradiation of “photo-Fenton reagent” (1) with calf thymus DNA in maximum yield of 1.1%. The ten-fold enhancement of the formation of 8-OHdG compared to the control level was observed in photoirradiation of L5178Y cells with 1. The 8-OHdG formation well corresponds to the site specific DNA-cleaving activity of 1 upon photoirradiation.This publication has 19 references indexed in Scilit:
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