THE VARIABILITY OF MEASUREMENT OF INULIN AND DIODRAST TESTS OF KIDNEY FUNCTION

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Abstract
The analysis of variance was carried out on inulin clearance (ClI), diodrast clearance (Cld), and diodrast Tm (TmD) on 40 subjects between 27 and 89 yrs. of age. Each subject had 2 tests on separate days consisting of 3-4 periods each. Significant differences between age groups, averaging 41, 64, and 81 yrs., were observed in all 3 functions. Standard deviations of period-to-period variations on the same test were 6.1 and 33 cc./min./1.73 sq. m. surface area for ClI and Cld, respectively, and 2.9 mg. I/min./1.73 sq. m. for diodrast Tm. The standard error of a single test was 12.8 cc./min. for Cll 93.5 cc./min for ClD, and 9 mg. I/min. for TmD. Individual differences contributed most of the variances, and period-to-period variance contributed least to the total.
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