AGE CHANGES IN GLOMERULAR FILTRATION RATE, EFFECTIVE RENAL PLASMA FLOW, AND TUBULAR EXCRETORY CAPACITY IN ADULT MALES
Open Access
- 1 May 1950
- journal article
- research article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 29 (5) , 496-507
- https://doi.org/10.1172/jci102286
Abstract
Renal clearance and Tm values commonly used as norms are based on measurements in individuals between ages of 17 and 68 yrs. A study of the age changes in inulin clearance (ClI), diodrast clearance (CId), and diodrast Tm (TmD) in 70 malc subjects between 24 and 89 yrs. of age with no evidence of frank cardiovascular renal disease. Uncomplicated arteriosclerosis was not ruled out. In 7 decades, ClI fell gradually from 122.8 to 65.3, ClD from 613.5 to 288.8 cc./min./1.73 sq. m. Filtration fraction (x 100) showed a small but significant increase. C1I/TmD did not change, but CID/TmD, the effective renal plasma flow per unit of excretory capacity, decreased significantly with age.Keywords
This publication has 5 references indexed in Scilit:
- THE VARIABILITY OF MEASUREMENT OF INULIN AND DIODRAST TESTS OF KIDNEY FUNCTIONJournal of Clinical Investigation, 1950
- NOTE ON THE INTERPRETATION OF CLEARANCE METHODS IN THE DISEASED KIDNEYJournal of Clinical Investigation, 1941
- RELATIONS OF EFFECTIVE RENAL BLOOD FLOW AND GLOMERULAR FILTRATION TO TUBULAR EXCRETORY MASS IN NORMAL MAN 1Journal of Clinical Investigation, 1940
- THE MEASUREMENT OF THE TUBULAR EXCRETORY MASS, EFFECTIVE BLOOD FLOW AND FILTRATION RATE IN THE NORMAL HUMAN KIDNEYJournal of Clinical Investigation, 1938
- CHANGES WITH AGE IN THE CARDIAC OUTPUT IN ADULT MENAmerican Journal of Physiology-Legacy Content, 1938