Host Response to Treponema pallidum Infection

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Abstract
Peripheral leukocytes of 67 rabbits infected intratesticularly with T. pallidum, Nichols'' strain for various lengths of time were examined by the migration inhibition test for their response to extracts of normal rabbit heart, skin, brain and T. pallidum antigen. A control group of 14 animals injected intratesticularly with extract of normal rabbit tests was similarly examined for leukocytes response to the same antigens responding to T. pallidum antigen with significant migration inhibition varied from 13-31. Transitional cellular response to heart and skin but not brain was observed (12-28%). Leukocytes of all but 2 control rabbits responded to the organ extracts within the limit of 2 SD. The response of the infected animals to the homologous organ extracts may suggest that during infection, lymphocytes are activated by the host tissue antigens.

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