The chemical nature of photoreactivable lesions in DNA.

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Abstract
The presence of thymine dimers in irradiated poly dA:dT and cytosine dimers in irradiated poly dI:dC, poly dG.dC, and poly dC is correlated with the ability of these substances to compete with transforming DNA for the photoreactivating enzyme. Heating polynucleotldes that contain cytosine dimers converts the dimers of uracil dimers, and the resulting polymers also compete. All three types of dimers are monomerized by the photo-reactivating enzyme, which also decreases the ability of the irradiated polymers to compete. Experiments on competing ability of irradiated DNA indicate that in the naturally occurring polynucleotides all these pyrimidine dimers also are substrates for the photoreactivating enzyme.

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