CORYNEBACTERIUM LIQUEFACIENS-INDUCED SUPPRESSOR T CELLS IN GRAFT-VERSUS-HOST REACTION

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Abstract
The effect of spleen cells and thymus cells from C. liquefaciens[Propionibacterium acnes]-treated (C57BL/6 .times. BALB/c)F1 hybrid mice on graft-vs.-host (GVH) reaction initiated in the parental to newborn F1 hybrid strain combination was studied using Simonsen''s spleen assay. Combined inocula of 5 .times. 106 normal BALB/c spleen cells and 50 .times. 106 spleen cells from F1 mice given i.v. injections of 1 mg C. liquefaciens yielded a significantly smaller spleen index than did 5 .times. 106 BALB/c spleen cells alone. This suppressive function of C. liquefaciens-treated F1 spleen cells was more potent in phagocyte-depleted and T [thymus-derived] cell-enriched cell fractions. Thymus cells from C. liquefaciens-treated F1 mice also suppressed GVH reaction. C. liquefaciens can induce suppressor T cells.

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