The potentiometric determination of polypeptides and amino-acids

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Abstract
A physicochemical study of the formol titration using the H electrode shows that primary amino acids and polypeptides react with up to 3 molecules of formaldehyde, and amino acids with 1 only, a tertiary compound (dimethyl-glycine) being without action. The reaction constants for a series of amino acids and 2 polypeptides were detd.; such constants are applicable to the reaction between formaldehyde and the amino acid either in the form of the zwitterion or the anion or both, it being impossible to decide in which form the amino acid reacts. A reaction mechanism is suggested.

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