A REVIEW OF 31 CASES OF STEVENS‐JOHNSON SYNDROME

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Abstract
Thirty-one cases of Stevens-Johnson syndrome over the past 18 years at the Prince Henry Hospital, Sydney, have been reviewed. Three cases following the administration of sulfamethoxypyridazine were described in detail. One of these was fatal; one was complicated by corneal ulcer, and the other by transverse myelitis, myositis, hepatopathy and thrush. The possible etiologies were discussed with particular reference to sulfamethoxypyridazine. The importance of appropriate dosage of this drug is stressed, and the importance of using it (and any other drug with possible side effects) only when necessary is obvious. Dare one suggest that the drug companies should make more mention of possible side effects in their advertising literature? The problems of therapy were also considered, emphasis being laid on the importance of general supportive measures.