IMMUNIZATION WITH HEAT-KILLED MYCOBACTERIUM PARATUBERCULOSIS IN MINERAL OIL. II

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Abstract
Heat-killed M. paratuberculosis in mineral oil, injd. into sheep in doses of 5-300 mg., elicited a powerful and protracted immunological response, including considerable infiltration at the site of injn. Smaller doses of 6-0.37 mg. of dried bacteria per sheep produced essentially similiar results, except that the infiltrates at the site of injn. were smaller and did not penetrate into the muscle. A few apparently intact acid-fast bacteria were found in the lesions of 8 of the 10 sheep employed. The skin sensitivity to avian tuberculin developed at least as regularly, and it lasted approx. as long with small doses as after larger doses. Complement-fixing antibodies developed in high titers, comparable to those observed after large doses.

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