Urinary Excretion, Tubular Reabsorption and Biliary Excretion of Cobalt 60 in Dogs

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Abstract
After a single intravenous injection of 20 [mu]g of Co60, as Co60SO4 /kg, between 40 and 70% of the injected dose may Be recovered in the urine plus the bile during a period of 7-13 hours. A large majority of this (nearly 90%) is recovered in the first 6 hours. Only 1/7 - 1/10 of total recovery is found in the bile. The 1st appearance of Co60 both in the urine and in the bile is within 10 minutes after intravenous injection. There is a "delay" of about 4 hours in the peak of the biliary excretion when compared with the peak of the urinary excretion. The renal clearance of Co6O within 3 hours after a single intravenous injection averages 27 ml/ min/M2 of surface area. About 3/4 of the filtration load is reabsorbed by the tubules. In experiments lasting up to 13 hours, renal clearances of Co60 decline due to an increase in the tubular reabsorption.