EFFECTS OF ANESTHETIC DOSAGE OF PENTOBARBITAL SODIUM ON RENAL FUNCTION AND BLOOD PRESSURE IN DOGS

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Abstract
Anesthesia induced in dogs by intraperit. adm. of 30 mg./kg. body wt. of pentobarbital Na does not usually impair renal function, for diodrast clearance and tubular secretory capacity as well as inulin clearance may be unaltered as compared with values observed in the resting conscious state. The maintenance unaltered of effective renal plasma flow (plasma diodrast clearance) and filtration fraction during the increase of arterial pressure induced by anesthesia indicates that the afferent arterioles have moderately constricted, in response, not to the anesthesia, but to the hypertension it causes. When renal failure occurs, it is associated with marked oliguria and with concurrent depression of diodrast and inulin clearances independently of changes in arterial pressure. Attention is drawn to the increase of arterial pressure commonly present during pentobarbital anesthesia in dogs. Levels of 110-120 mm. Hg which might be accepted as normal in conscious dogs may express toxic depression under pentobarbital anesthesia. The onset of severe oliguria, indicating as it does the onset of renal failure, may provide a more delicate index of the toxic effects of the anesthetic than does a decrease of arterial pressure.

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