Effect of strontium chloride on bone resorption induced by prostaglandin E2 in cultured bone
- 1 January 1988
- journal article
- research article
- Published by Springer Nature in Archives of Toxicology
- Vol. 62 (2-3) , 240-241
- https://doi.org/10.1007/bf00570150
Abstract
We examined whether the bone resorption induced by PGE2 was inhibited by SrCl2 using45Ca-labelled calvaria of CD-strain mice in tissue culture. It was found that Sr salts inhibited physiological bone resorption in a dose-dependent manner (0.1–5.0 mM) and did not act via PGE2. Accordingly, it was suggested that Sr salts did not inhibit bone resorption induced by exogenous PGE2.Keywords
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