Soluble II-2 receptor serum levels ? a marker for disease progression in patients with HIV-1 infection

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Abstract
Serum levels of soluble II-2 receptors (sII-2R) were measured in 88 patients with HIV infection, 28 patients from high-risk groups, and 28 normal donors. Elevated sII-2R levels were found in 46% of asymptomatic seropositive patients, in 68% of patients with persistent generalized lymphadenopathy, and in 81% of patients with AIDS. Mean sII-2R values increased with the progression of the disease and were most pronounced in patients with AIDS. A close correlation was found between sII-2R levels and beta2-microglobulin (p<0.0001) and other prognostic parameters known to parallel clinical activity. In addition to being a valuable parameter in monitoring the course of the HIV infection, elevated sII-2R levels may also be involved in the down-regulation of II-2-dependent immune functions in AIDS.

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