Effect of anti-inflammatory agents on corneal wound-healing process after surface excimer laser keratectomy
- 1 March 2000
- journal article
- research article
- Published by Wolters Kluwer Health in Journal of Cataract & Refractive Surgery
- Vol. 26 (3) , 426-431
- https://doi.org/10.1016/s0886-3350(99)00358-2
Abstract
To investigate the effect of anti-inflammatory agents on conjunctival inflammation and corneal haze formation after excimer laser keratectomy. Department of Ophthalmology, University of Tokyo Faculty of Medicine, Tokyo, Japan. After excimer laser keratectomy was performed in 21 rabbits (42 eyes), saline, betamethasone 0.1%, or diclofenac 0.1% was topically applied 6 times a day for 4 weeks and then 3 times a day for 8 weeks. The degree of conjunctival inflammation was determined 1, 2, 3, and 7 days after the keratectomy. The degree of corneal haze was quantitatively measured using a digital analyzer before and once a week after the keratectomy. The expression of type IV collagen in the corneas at baseline and 4 and 12 weeks after the keratectomy was examined immunohistochemically. Compared with saline, betamethasone and diclofenac significantly decreased early-phase conjunctival inflammation. Betamethasone significantly inhibited corneal haze formation compared with saline at 3 to 5 and 8 to12 weeks. Diclofenac did not inhibit corneal haze formation significantly. Although betamethasone tended to be more effective in inhibiting corneal haze formation and deposition of type IV collagen than diclofenac, there was no statistical difference between the 2 anti-inflammatory agents. Topically applied betamethasone effectively suppressed corneal haze formation after excimer laser keratectomy. Diclofenac was not statistically effective in inhibiting corneal haze formation.Keywords
This publication has 17 references indexed in Scilit:
- Effects of transforming growth factor β on corneal epithelial and stromal cell function in a rat wound healing model after excimer laser keratectomyAlbrecht von Graefes Archiv für Ophthalmologie, 1998
- Complications of photorefractive keratectomy for myopia: Two year follow-up of 3000 casesJournal of Cataract & Refractive Surgery, 1998
- Expression of transforming growth factor beta superfamily and their receptors in the corneal stromal wound healing process after excimer laser keratectomyBritish Journal of Ophthalmology, 1998
- Effect of topical anti-transforming growth factor-β on corneal stromal haze after photorefractive keratectomy in rabbitsJournal of Cataract & Refractive Surgery, 1997
- Complications of excimer laser photorefractive keratectomy for myopiaJournal of Cataract & Refractive Surgery, 1997
- Effect of Diclofenac on Corneal Haze after Photorefractive Keratectomy in RabbitsOphthalmology, 1995
- Expression of cellular fibronectin and tenascin in the rabbit cornea after excimer laser photorefractive keratectomy: a 12 month study.British Journal of Ophthalmology, 1995
- Use of topical nonsteroidal anti-inflammatory drugs in excimer laser photorefractive keratectomyJournal of Cataract & Refractive Surgery, 1994
- The Effect of Topical Corticosteroids on Refractive Outcome and Corneal Haze After Photorefractive KeratectomyArchives of Ophthalmology (1950), 1992
- Corneal Stromal Wound Healing in Rabbits After 193-nm Excimer Laser Surface AblationArchives of Ophthalmology (1950), 1989