Reaction of a nucleoside 2,4-dinitrophenyl phosphate with fluoride; A convenient method for the preparation of the nucleoside phosphorfluoridate
- 1 January 1975
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 2 (10) , 1745-1750
- https://doi.org/10.1093/nar/2.10.1745
Abstract
Examination of the reaction of 2, 4-dinitrofluorobenzene with thymidine-5' phosphate in detail reveals that the initial product is the 2, 4-dinitrophenyl ester. This reacts with fluoride to produce thymidine-5' phosphorfluoridate. This second reaction provides the basis for the conversion of preformed thymidine-5' 2, 4-dinitrophenyl phosphate to thymidine-5' phosphorofluoridate.Keywords
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