Pulmonary Vascular Changes in the Mouse During Anaphylactic Shock.

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Abstract
Direct microscopic observation of the living pulmonary circulation of mice was performed using the quartz rod method of Knisely. Mice were sensitized intra-peritoneally with 0.1 ml of Hemophilus pertussis vaccine and 0.05 ml of horse serum. Challenge doses of horse serum (0.2 ml) were given intravenously 10-20 days later. Pulmonary blood flow was noted before and after the intravenous challenge dose of horse serum. Arteriolar constriction, clumping of red cells and embolization were observed.

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