Endocrine fibroblast growth factors 15/19 and 21: from feast to famine
Top Cited Papers
- 2 February 2012
- journal article
- review article
- Published by Cold Spring Harbor Laboratory in Genes & Development
- Vol. 26 (4) , 312-324
- https://doi.org/10.1101/gad.184788.111
Abstract
We review the physiology and pharmacology of two atypical fibroblast growth factors (FGFs)—FGF15/19 and FGF21—that can function as hormones. Both FGF15/19 and FGF21 act on multiple tissues to coordinate carbohydrate and lipid metabolism in response to nutritional status. Whereas FGF15/19 is secreted from the small intestine in response to feeding and has insulin-like actions, FGF21 is secreted from the liver in response to extended fasting and has glucagon-like effects. FGF21 also acts in an autocrine fashion in several tissues, including adipose. The pharmacological actions of FGF15/19 and FGF21 make them attractive drug candidates for treating metabolic disease.Keywords
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