Studies Concerning the Mechanism by which Translational‐Control RNA Regulates Protein Synthesis in Embryonic Muscle
- 1 October 1975
- journal article
- Published by Wiley in European Journal of Biochemistry
- Vol. 58 (2) , 587-593
- https://doi.org/10.1111/j.1432-1033.1975.tb02409.x
Abstract
Muscle translational‐control RNA (tcRNA) has been separated into two classes, polysomal and messenger ribonuclear protein (mRNA · protein), which have different sizes as determined by acrylamide gel electrophoresis. While normally translation of mRNA · protein mRNA is inhibited by tcRNA derived from the same mRNA · proteins, this inhibition does not occur if the messenger is previously de‐adenylated. This suggests that the poly(A) segment of mRNA is required for the tcRNA activity. Utilizing different mRNA · protein fractions from muscle, myosin mRNA · protein and small mRNA · proteins (1 and T2 RNase.Keywords
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