TURNOVER OF LABELED NORMAL GAMMA GLOBULIN IN MULTIPLE MYELOMA*
Open Access
- 1 April 1960
- journal article
- research article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 39 (4) , 565-572
- https://doi.org/10.1172/jci104069
Abstract
The turnover of I131-labeled normal gamma globulin was determined in 10 patients with multiple myeloma and correlated with the serum globulin distribution as established by paper electrophoresis. In the beta type individuals, the mean of the half-life was 16.12 [plus or minus] 1.15 days, and for the gamma type, 7.14 [plus or minus] 0.28 days. The rate of degradation for normal gamma globulin indicated by the slow component was far more rapid for the patient with excessive gamma globulin in his serum protein distribution than for the individual with excessive beta globulin.Keywords
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