Vascular changes in the lungs of rats after the intravenous injection of pyrrole carbamates

Publisher Website
Google Scholar
Abstract
The effects on the lung of some synthetic compounds related to monocrotaline pyrrole were studied and compared with those previously found with that compound. When injected into a systemic vein doses of pyrrole mono- and dicarbamate produced acute pulmonary edema. Pyrrole alcohol and ethyl carbamate had no such effect and although furyl carbamate did not cause pleural effusion in rats it did so in mice. Like monocrotaline pyrrole, when injected into other vessels the pyrrole carbamates produced edema in the region of the 1st capillary bed encountered. When colloidal carbon was injected i.v. after the pyrrole carbamates, carbon labeling was seen in both the post-capillary venilles and the capillaries of the lungs. On the whole, venular labeling occurred before capillary which was best seen when the carbon was injected more than 4 h after the pyrrole. The distribution of the carbon as seen by EM is described. No labeling was seen after furyl carbamate. The effects of the synthetic pyrrole esters were similar to those of monocrotaline pyrrole. Although both the pyrrole carbamates were less active on a molecular basis they had a broader action on the pulmonary vasculature causing venular as well as capillary labeling. To affect the lungs acutely the compound had to have the pyrrole ring structure and at least 1 ester side-chain.