A Simplified Serological Test for Leprosy Based on a 3,6-di-O-Methylglucose-Containing Synthetic Antigen
- 1 January 1986
- journal article
- research article
- Published by American Society of Tropical Medicine and Hygiene in The American Journal of Tropical Medicine and Hygiene
- Vol. 35 (1) , 167-172
- https://doi.org/10.4269/ajtmh.1986.35.167
Abstract
The recent advent of synthetic antigens containing the Mycobacterium leprae-specific epitope, 3,6-di-O-methyl-β-d-glucopyranoside, has allowed the development of simple specific serological tests for leprosy. The incorporation of one such product, 8-carbonyloctylO-[4-O-(3,6-di-O-methyl-β-d-glucopyranosyl)-α-l-rhamnopyranoside]-BSA, into a simple “spot” test, diffusion-in-gel enzyme-linked immunosorbent assay (ELISA), allowed an over 90% detection rate of untreated lepromatous leprosy, and the results showed good concordance with conventional ELISA based on the native phenolic glycolipid I.This publication has 14 references indexed in Scilit:
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