Detection of a cell-surface antigen correlated with organ-specific metastasis

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Abstract
Despite the fact that tumor cells with the potential for metastasis may circulate randomly, many demonstrate a preference for specific organs. The derivation of a liver-specific metastatic variant of a Marek''s disease (MD) virus-transformed, non-producer lymphoma cell line was recently reported. MD is a naturally occurring, herpes virus-induced, T-cell lymphoma of chickens which bears pathological and etiological similarities to Burkitt''s lymphoma in man. This makes MD a useful model for study. One similarity is the pattern of metastasis in which both lymphomas induce a high incidence of ovarian and liver lesions. The existence of a cell-surface antigen, detectable by a monoclonal antibody, correlated with organ-specific metastasis.