Chromosome damage and SCE induced by the cytostatic factor homo‐aza‐steroidal ester of P‐bis (2‐chloro‐ethyl) amino phenyl acetic acid in CHO cells in culture
- 1 January 1983
- journal article
- research article
- Published by Wiley in Environmental Mutagenesis
- Vol. 5 (3) , 279-283
- https://doi.org/10.1002/em.2860050306
Abstract
The cytogenetic effects of homo-aza-steroidal ester (ASE) on Chinese hamster ovary (CHO) cells in vitro are reported. It was found that treatment of cells with a dose as low as 0.025 μg/ml of ASE causes a significant number of abnormal metaphases containing mostly chromatid-type aberrations. Similarly, significant frequencies of SCE were induced with only 0.075 μg/ml of ASE.Keywords
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