Microfluidics-Based Biochips: Technology Issues, Implementation Platforms, and Design-Automation Challenges
- 21 February 2006
- journal article
- Published by Institute of Electrical and Electronics Engineers (IEEE) in IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
- Vol. 25 (2) , 211-223
- https://doi.org/10.1109/tcad.2005.855956
Abstract
Microfluidics-based biochips are soon expected to revolutionize clinical diagnosis, deoxyribonucleic acid (DNA) sequencing, and other laboratory procedures involving molecular biology. In contrast to continuous-flow systems that rely on permanently etched microchannels, micropumps, and microvalves, digital microfluidics offers a scalable system architecture and dynamic reconfigurability; groups of unit cells in a microfluidics array can be reconfigured to change their functionality during the concurrent execution of a set of bioassays. As more bioassays are executed concurrently on a biochip, system integration and design complexity are expected to increase dramatically. This paper presents an overview of an integrated system-level design methodology that attempts to address key issues in the synthesis, testing and reconfiguration of digital microfluidics-based biochips. Different actuation mechanisms for microfluidics-based biochips, and associated design-automation trends and challenges are also discussed. The proposed top-down design-automation approach is expected to relieve biochip users from the burden of manual optimization of bioassays, time-consuming hardware design, and costly testing and maintenance procedures, and it will facilitate the integration of fluidic components with a microelectronic component in next-generation systems-on-chips (SOCs).Keywords
This publication has 38 references indexed in Scilit:
- Combined circuit/device modeling and simulation of integrated microfluidic systemsJournal of Microelectromechanical Systems, 2005
- Principles of droplet electrohydrodynamics for lab-on-a-chipLab on a Chip, 2004
- Physical and reduced-order dynamic analysis of MEMSPublished by Institute of Electrical and Electronics Engineers (IEEE) ,2003
- Evaluation of placement techniques for DNA probe array layoutPublished by Institute of Electrical and Electronics Engineers (IEEE) ,2003
- Design methodology for mixed-domain systems-on-a-chip [MEMS design]Published by Institute of Electrical and Electronics Engineers (IEEE) ,2002
- Electrowetting-based actuation of droplets for integrated microfluidicsElectronic supplementary information (ESI) available: six videos showing droplet flow, droplet dispensing and electrowetting. See http://www.rsc.org/suppdata/lc/b1/b110474h/Lab on a Chip, 2002
- Dielectrophoretic liquid actuation and nanodroplet formationJournal of Applied Physics, 2001
- A hierarchical circuit-level design methodology for microelectromechanical systemsIEEE Transactions on Circuits and Systems II: Analog and Digital Signal Processing, 1999
- An Integrated Nanoliter DNA Analysis DeviceScience, 1998
- Electrostatic actuation of liquid droplets for micro-reactor applicationsIEEE Transactions on Industry Applications, 1998