GΓ andAΓ globin chain synthesis in bone marrow and peripheral blood of β-thalassaemia homozygotes
- 1 October 1982
- journal article
- research article
- Published by Wiley in British Journal of Haematology
- Vol. 52 (2) , 225-231
- https://doi.org/10.1111/j.1365-2141.1982.tb03884.x
Abstract
G.gamma., A.gamma. and .beta. globulin chain synthesis was investigated in the peripheral blood and bone marrow from 8 .beta.-thalassaemia homozygotes. In 5 out of 8 cases total .gamma. chain synthesis was higher in the peripheral blood than in the bone marrow; in 7 out of 8 cases A.gamma. chain synthesis was markedly higher in the marrow than in the peripheral blood. Ineffective erythropoiesis evidently selects F-cells synthesizing the largest amounts of G.gamma. chains, while A.gamma. producing cells are preferentially destroyed in the marrow.This publication has 28 references indexed in Scilit:
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