Sequential methotrexate and 5-fluorouracil: improved response rate in metastatic colorectal cancer.
- 1 June 1984
- journal article
- research article
- Published by American Society of Clinical Oncology (ASCO) in Journal of Clinical Oncology
- Vol. 2 (6) , 591-594
- https://doi.org/10.1200/jco.1984.2.6.591
Abstract
The efficacy of chemotherapy with sequential methotrexate (MTX) and 5-fluorouracil (5-FU) in metastatic colorectal cancer was studied in a multicenter phase II trial using a 7-h time interval. Patients (42) were evaluable for response and 16 achieved objective tumor regression (> 50%). Median survival of all patients was 12.5 mo. MTX and 5-FU are synergistic in human colorectal cancer if given sequentially with a 7-h time interval. This is supported by a review of the literature that reveals a significantly higher response rate in patients treated with a 4 h or more MTX/5-FU interval as compared to a 1 h interval.This publication has 11 references indexed in Scilit:
- Metastatic colorectal carcinoma: A prospective randomized trial of Methyl-CCNU, 5-fluorouracil (5-FU) and vincristine (MOF) versus MOF plus streptozotocin (MOF-strep)Cancer, 1983
- PHASE-II STUDY OF SEQUENTIAL METHOTREXATE-5-FU THERAPY IN ADVANCED MEASURABLE COLORECTAL-CANCER1982
- Preliminary report on the efficacy of sequential methotrexate and 5-fluorouracil in advanced breast cancerCancer, 1981
- The influence of methotrexate pretreatment on 5-fluorouracil metabolism in L1210 cells.Journal of Biological Chemistry, 1981
- MODULATION OF 5-FLUOROURACIL METABOLISM AND CYTO-TOXICITY BY ANTI-METABOLITE PRETREATMENT IN HUMAN COLORECTAL ADENOCARCINOMA HCT-81981
- Survival and response to chemotherapy for advanced colorectal adenocarcinoma. An eastern cooperative oncology group reportCancer, 1980
- EFFECTIVENESS OF INTERMEDIATE-DOSE METHOTREXATE AND HIGH-DOSE 5-FLUOROURACIL AS SEQUENTIAL COMBINATION CHEMOTHERAPY IN REFRACTORY BREAST-CANCER AND AS PRIMARY THERAPY IN METASTATIC ADENOCARCINOMA OF THE COLON1980
- The clinical pharmacology of methotrexate.new applications of an old drugCancer, 1978
- SCHEDULE-DEPENDENT ANTITUMOR EFFECTS OF METHOTREXATE AND 5-FLUOROURACIL1977
- A phase III study comparing the clinical utility of four regimens of 5-Fluorouracil.A preliminary reportCancer, 1977