Efficient and Selective Synthesis of Siphonarienolone and Related Reduced Polypropionates via Zr-Catalyzed Asymmetric Carboalumination
- 25 March 2004
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 6 (9) , 1425-1427
- https://doi.org/10.1021/ol0497483
Abstract
Siphonarienolone (1) has been synthesized from siphonarienal (3) in 66% over four steps. Synthesis of 3, in turn, has been achieved in two steps (85% combined yield) from 4, prepared from 3-buten-1-ol in seven steps (23% combined yield). Also, a two-step conversion of 3 into siphonarienone (2) is reported.Keywords
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