Methods of Evaluating Tin and Fluoride Salts as Anticaries Agents in Animal Caries Experiments

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Abstract
The anticaries effectiveness of 3 materials fed in the water or topically applied was investigated using the Wistar rat on a modified Stephan Diet (580). At levels of 10 ppm F and/or 31 ppm Sn(II) in the drinking water, stannous fluoride effectively reduced caries incidence (31%) while sodium fluoride (9% reduction) and stannous chloride (2% reduction) were essentially ineffective. With topical application at low concentration (0.1% SnF2, 0.05% NaF), stannous fluoride was more effective than sodium fluoride. At high concentration (2 and 8% SnF2, 2 and 4% NaF), these 2 materials were equal in their caries reducing effect while stannous chloride (2%) was ineffective. The more frequent the topical application, the more effective was the caries reduction evoked. There was a difference in response among the 3 molars. All materials were more effective on the third molar.