Rga (Rodgers) and the HLA Region: Linkage and Associations
- 1 October 1976
- journal article
- Published by Wiley in Tissue Antigens
- Vol. 8 (4) , 143-149
- https://doi.org/10.1111/j.1399-0039.1976.tb00578.x
Abstract
In 19 families with 97 children the segregation of Rga (Rodgers) was found to be compatible with Mendelian inheritance and five backcross and 14 intercross families were found among HLA and Bf typed families. Close linkage (lods + 17.82) without recombination was found between Rg and the HLA region, with a direct count of 96 nonrecombinant meioses for Rg‐HLA‐B. Kg‐ was strongly associated with HLA‐B8 (29 of 30 haplotypes) and probably associated with Bw40, but did occur on other HLA‐B haplotypes. By inference .Rg‐ is negatively associated with Ch‐ (Chido). The Rg‐Ch‐ haplotype has not been observed. Rg3 and Cha may or may not be coded for by different sites of the same cistron closely linked to HLA‐B:C and cannot as yet be excluded from being parts of B or C.Keywords
This publication has 11 references indexed in Scilit:
- Bf Maps between the HLA-A and D LociTissue Antigens, 2008
- A New Antibody Specificity, Anti‐Rga, Reacting with a Red Cell and Serum AntigenVox Sanguinis, 1976
- The HL‐A Type of Rg(a–) IndividualsVox Sanguinis, 1976
- The Localization of the Bf Locus within the MHS Region on Chromosome No. 6Tissue Antigens, 1976
- Recombination between the Second and Third Series of the HL‐A SystemTissue Antigens, 1975
- On the Localization of the Gb Locus within the MHS Region of Chromosome No. 6Tissue Antigens, 1975
- The Bf locus in the HLA region of chromosome 6: Linkage and association studiesHuman Genetics, 1975
- C3 polymorphism: Genetic linkage relationsClinical Genetics, 1974
- Linkage of Chido and HL‐ATissue Antigens, 1974
- Chido‐Substance in PlasmaVox Sanguinis, 1972