The lipids of whole blood. 1. Lipid biosynthesis in human blood in vitro

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Abstract
The cellular components of human blood are shown to be a convenient system for studies of fatty acid and lipid synthesis and exchange. After incubation of whole blood with[Me-C14]acetate all the common saturated and unsaturated acids are found to be labeled, including the mono- and poly-unsaturated acids of a variety of chain lengths. The "essential" fatty acids arachidonic acid, and linoleic acid or linolenic acid or both, are also labeled. The long-chain fatty acids are incorporated into triglycerides and some neutral lipids of undefined structure, as well as into phospholipids, but not into cholesterol esters. The triglycerides and other neutral lipids are rapidly secreted into plasma, where they are incorporated into the plasma a -lipoproteins but not into B-lipoprotein. The phospholipids are more readily incorporated into the plasma B-lipoproteins.
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