Effects of duodenal perfusion with sodium taurocholate on biliary and pancreatic secretion in man

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Abstract
The effects of intraluminal sodium taurocholate (STC) on biliary and pancreatic secretion were studied in man using a duodenal perfusion technique and indocyanine green (ICG) as an exogenous biliary marker. Duodenal perfusion wih 15 or 30 mmol/l STC in healthy subjects markedly suppressed caerulein and secretin stimulated biliary indocyanine green (ICG) excretion in a dose responsive manner, i.e., to 40% (17-95%, .+-. 2 SD, n = 5) (P < 0.025) and 32% (26-38%, .+-. 2 SD, n = 3) (P < 0.003) of i.v. ICG infusion, respectively, with a maximum suppression to 26% and 10%, respectively. In cholecystectomized subjects (n = 5), significant changes in ICG excretion were not observed during STC (15 mmol/l) perfusion. There were no suppressive effects on pancreatic enzyme or bicarbonate secretion in any of the subjects. The bile salt STC in the duodenum in man probably activated a mechanism which selectively suppressed biliary excretion. This is probably due to relaxation of the gallbladder and an increase in gallbladder storage of bile.