Stimulation of Bile and Pancreatic Secretion by Duodenal Perfusion with Na-Taurocholate in the Cat Compared with Jejunal and Ileal Perfusion

Publisher Website
Google Scholar
Abstract
In the anesthetized cat duodenal perfusion with Na taurocholate (TC, 0.2 M, pH 6.1, 290 mosmol, 45 ml .times. h-1) stimulated pancreatic volume (0 to 326 .+-. 236 mg .times. 10 min-1) and bicarbonate secretion (0 to 34.2 .+-. 4.1 .mu.mol .times. 10 min-1), while pancreatic enzyme output was sparse. Simultaneously with the pancreatic response, bile flow increased from 139 .+-. 74 mg to 484 .+-. 146 mg .times. 15 min-1 (P < 0.05). During perfusion of the upper jejunum pancreatic and biliary responses were significantly lower than the responses to duodenal TC perfusion (P < 0.05). During TC perfusion of the terminal ileum there was no response from the pancreas, while the increase in bile flow accounted only for an increase in the bile-acid-dependent fraction. The concomitant stimulation of the hydrokinetic function of the pancreas and the bile-acid-independent bile flow might be mediated by a release of secretin.