VIRAL AND VIRAL PROTEIN SPECIFICITY OF ANTIBODIES INDUCED IN COWS PERSISTENTLY INFECTED WITH NONCYTOPATHIC BOVINE VIRAL DIARRHEA VIRUS AFTER VACCINATION WITH CYTOPATHIC BOVINE VIRAL DIARRHEA VIRUS

  • 1 July 1988
    • journal article
    • research article
    • Vol. 49  (7) , 1040-1044
Abstract
Neutralizing and nonneutralizing antibodies to bovine viral diarrhea (BVD) virus were detected in 3 cows persistently infected with noncytopathic BVD virus after vaccination with modified-live cytopathic BVD virus. Neutralizing antibodies detected in serum samples from each persistently infected cow at 3 weeks after vaccination were highly specific for certain isolates of cytopathic BVD virus and reacted only with a viral protein with a molecular weight of 53,000. Neutralizing antibodies to 1 of 3 isolates of noncytopathic BVD virus were detected in a serum sample obtained at 12 weeks after vaccination from 1 of 3 persistently infected cows. Nonneutralizing antibodies were detected in all cows at 7 to 12 weeks after vaccination. The nonneutralizing antibodies were less specific for isolates of BVD virus and reacted with viral proteins with molecular weights of 115,000, 80,000, 53,000, and 47,000.