STUDIES ON THE METABOLISM OF MYCOBACTERIUM TUBERCULOSIS II

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Abstract
By employing quantitative growth studies and a basal synthetic medium from which the normal C source, glycerol, was omitted, it was found that pyruvic, acetic, oxalacetic, oxalosuccinic, alpha-ketoglutaric acids, lactic acid, and glycerol supported the growth of the virulent human type strain H37Rv of M. tuberculosis. cis-Aconitic, isocitric, succinic, fumaric, L-malic, and citric acids did not support growth; nor did the 3 amino acids, glutamic acid, aspartic acid, and DL-alanine. The relation of these findings to the operation of the Kreb''s tricarboxylic acid cycle in the intermediary carbohydrate metabolism of M. tuberculosis var. hominis was discussed.

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