No association betweenCALHM1variation and risk of Alzheimer disease
Open Access
- 20 March 2009
- journal article
- mutation in-brief
- Published by Hindawi Limited in Human Mutation
- Vol. 30 (4) , E566-E569
- https://doi.org/10.1002/humu.20989
Abstract
A polymorphism in the calcium homeostasis modulator 1 gene (CALHM1) has recently been associated with risk of late‐onset Alzheimer disease. We examined this variant (rs2986017) in 945 Caucasian Americans with late‐onset Alzheimer disease and 875 age‐matched Caucasian American controls. No association with risk of late‐onset Alzheimer disease (p=0.368 for genotypes; p=0.796 for alleles) was observed in our sample. However, a potential modest association of minor allele homozygosity (TT) with an earlier age‐at‐onset was seen (p=0.034).Keywords
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