Suppression of Transduodenal Manganese Transport by Milk Diet Supplemented with Iron

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Abstract
The effect of iron on manganese transport through, and its retention in, the duodenal wall was studied in 5-week-old female albino rats. Animals were fed only cow’s milk supplemented with different doses of ferrous sulphate (0.60–19.0 mg Fe/100 ml) for 3 days before killing. Manganese transport was studied in vitro by the method of ‘everted gut sac’. In all rats fed milk supplemented with iron the manganese transport through, and its retention within, the intestinal wall was significantly lower than when no iron was given (0.001 > p < 0.001). The suppression of both the transfer and intestinal retention of manganese suggests a saturation effect produced by iron which levels off above 5 mg Fe/100 ml milk.