Anterior Pituitary Growth Hormone (STH) and Pancreatic Secretion of Glucagon (HGF).

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Abstract
Fourteen cross-circulation expts. were performed by anastomosing the pancreato-duodenal or a mesenteric vein of a donor dog D with a femoral vein of a recipient dog R. The intraven. injn. of purified anterior pituitary STH into a normal donor or into a donor previously treated with the same STH causes the appearance of a hyperglycemic material (glucagon) in the blood of the pancreatic but not the mesenteric vein. This glucagon causes hyperglycemia in a normal recipient dog. STH appears to cause hyperglycemia by stimulating the secretion of glucagon by the pancreas.