Effect of a Histamine H2Type Receptor Antagonist (WY 45, 727) on the Healing of Gastric Ulcers in Ponies

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Abstract
Using video gastroscopy, the efficacy of a Histamine‐H2type receptor antagonist (WY 45, 727) was investigated in young ponies with spontaneous and experimentally induced gastric ulcers. Oral administration of WY 45,727 at 2 mg/kg and 10 mg/kg of body weight every 12 hours for 14 days resulted in complete healing of spontaneous gastric ulcers in the non‐glandular portion of the stomach in 2/5 (40%) and 3/4 (75%) of the ponies, respectively, compared (P>0.05) to 0/5 (0%)placebo‐treated ponies. After intramuscular administration of flunixin meglumine at 1.5 mg/kg body weight every 8 hours for 6 days, 9/18 ponies had ulcers in the non‐glandular portion of the stomach. Oral administration of WY 45,727 at 10 mg/kg body weight every 12 hours for 14 days resulted in complete healing of the non‐glandular gastric ulcers in 3/4 (75%) compared with (P> 0.05) 1/5 (20%) placebo‐treated ponies. This study indicates that 1) the occurrence of subclinical ulcers may be common in young ponies; 2) flunixin meglumine at 1.5 mg/kg intramuscularly every 8 hours for 6 days may result in ulcers of the non‐glandular stomach in ponies; and 3) WY 45,727, a histaminergic H2type receptor antagonist could be of value in the therapeutic management of ulcers in the non‐glandular stomach of foals and adult horses. (Journal of Veterinary Internal Medicine 1992; 6:271–275)

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