Serum Transaminase Levels

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Abstract
THE ENZYME glutamic oxalacetic transaminase (GOT) is widely distributed in animal tissues, its concentrations being greatest in myocardial and skeletal muscle, liver, brain, and kidney.1 Besides its common use in diagnoses of diseases of the heart and liver,2 serum glutamic oxalacetic transaminase (SGOT) has been employed in the diagnosis of various disturbances of skeletal muscle, including dermatomyositis,3 muscular dystrophy,4 primary myoglobinuria,5,6 muscle trauma,7 and after arterial embolism to an extremity.8 The effect of strenuous and prolonged physical exercise on the SGOT level has not been studied in humans. Critz and Merrick9 found no elevation in level in human subjects after mild exercise. Schland10 studied 27 servicemen during and immediately after a brief period of moderate exercise and found mild SGOT elevations, the highest being 96 units. Altland and Highman11 observed moderate elevations in rats of SGOT levels and focal