THE EFFECT OF THYROID TREATMENT ON THE RESPIRATION OF VARIOUS RAT TISSUES1

Abstract
A study of the effects of thyroid adm. on the O2 consumption of albino rat tissues showed significant increases in liver, kidney, diaphragm and heart. No effect was observed with spleen, brain or testis. Each tissue showed a different, but characteristic, rate and extent of change. Decreases in R.Q. even in the presence of glucose and glycogen were noted for hyperthyroid liver and diaphragm. Kidney R.Q. was increased. By means of substrates and inhibitors, it was found that thyroid activity alters the ability of these tissues to utilize certain metabolites.

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